"And now I know that none of you, among whom I have gone about proclaiming the kingdom, will ever see my face again.  Therefore I declare to you this day that I am not responsible for the blood of any of you.  For I did not shrink from declaring to you the whole purpose of God.  Keep watch over yourselves and over all the flock, of which the Holy Spirit has made you overseers, to shepherd the church of God that He obtained with the blood of His own Son.  I know that after I have gone, savage wolves will come in among you, not sparing the flock.  Some even from your own group will come distorting the truth in order to entice the disciples to follow them."

Paul is removing himself completely from the Ephesian church.  He is make a complete transfer:  No longer am I in charge of our spiritual growth - you are in charge of it.  He says, 'Your blood is not on my hands, it is on yours.'

Then we get a glimpse of some of the things that Paul must have struggled with during his tenure in Asia.  The wolves will come to destroy.  Some from your own flock will try to entice the disciples to go astray.  But Paul has an answer for these problems.

The Holy Spirit gave you the calling to be overseers.

What calling does the Holy Spirit give to you?

Since the Holy Spirit is in charge, Paul is not worried.  He would place the calling and prompting of the Spirit against the wolves of religion any day.

Trust in God - His calling on your life means something.